Christopher Hitchens on Hatred, the Left, and His Favourite Authors - P. G. Wodehouse (1993)

Hitchens was known for his scathing critiques of public figures. Three figures—Bill Clinton, Henry Kissinger, and Mother Teresa—were the targets of three separate full length texts, No One Left to Lie To: The Triangulations of William Jefferson Clinton, The Trial of Henry Kissinger, and The Missionary Position: Mother Teresa in Theory and Practice. Hitchens also wrote book-length biographical essays about Thomas Jefferson (Thomas Jefferson: Author of America), George Orwell (Why Orwell Matters), and Thomas Paine (Thomas Paine's "Rights of Man": A Biography).

However, the majority of Hitchens's critiques took the form of short opinion pieces, some of the more notable being his critiques of: Jerry Falwell,[103][104] George Galloway,[105] Mel Gibson,[106] Tenzin Gyatso, the 14th Dalai Lama,[107] Michael Moore,[108] Daniel Pipes,[109] Ronald Reagan,[110] Jesse Helms,[111] and Cindy Sheehan.[19][112] When comedian Bob Hope died in 2003, Hitchens wrote an attack piece on him, calling Hope "a fool and nearly a clown, but he was never even remotely a comedian" and "Quick, then—what is your favorite Bob Hope gag? It wouldn't take you long if I challenged you on Milton Berle, or Woody Allen, or John Cleese, or even Lenny Bruce or Mort Sahl. By this time tomorrow, I bet you haven't come up with a real joke for which Hope could take credit." Critics argued that Hitchens focused solely on Hope's declining years and ignored his heyday in the 1940s.

Former British Prime Minister Tony Blair said, "Christopher Hitchens was a complete one-off, an amazing mixture of writer, journalist, polemicist, and unique character. He was fearless in the pursuit of truth and any cause in which he believed. And there was no belief he held that he did not advocate with passion, commitment, and brilliance. He was an extraordinary, compelling and colourful human being whom it was a privilege to know."[176]
Richard Dawkins, British evolutionary biologist at the University of Oxford and a friend of Hitchens, said, "I think he was one of the greatest orators of all time. He was a polymath, a wit, immensely knowledgeable, and a valiant fighter against all tyrants including imaginary supernatural ones."[176]
Sam Harris, American writer and neuroscientist, wrote, "I have been privileged to witness the gratitude that so many people feel for Hitch's life and work—for, wherever I speak, I meet his fans. On my last book tour, those who attended my lectures could not contain their delight at the mere mention of his name—and many of them came up to get their books signed primarily to request that I pass along their best wishes to him. It was wonderful to see how much Hitch was loved and admired—and to be able to share this with him before the end. I will miss you, brother."[177]
Francis Collins, director of the National Institutes of Health and former head of the Human Genome Project who helped treat Hitchens' illness, wrote, "I will miss Christopher. I will miss the brilliant turn of phrase, the good-natured banter, the wry sideways smile when he was about to make a remark that would make me laugh out loud. No doubt he now knows the answer to the question of whether there is more to the spirit than just atoms and molecules. I hope he was surprised by the answer. I hope to hear him tell about it someday. He will tell it really well."[178]
The American Catholic columnist Ross Douthat, noting the affection felt by intellectually minded Christians for Hitchens, observed that, "in the world of journalism, among his peers and competitors and sparring partners, it was nearly impossible to find a religious person who didn't have a soft spot for a man who famously accused faith of poisoning absolutely everything."[179]
British columnist and author Peter Hitchens, who had a tumultuous relationship with his older brother Christopher, wrote that he and Christopher "got on surprisingly well in the past few months, better than for about 50 years as it happens", and praised his brother as "courageous".